Cordycepin production by Cordyceps militaris cultivation on spent brewery grains

Cordycepin production by Cordyceps militaris cultivation on spent brewery grains

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This is a first report on C.militaris mycelia and fruiting bodies cultivation on solid-state containing spent brewery grains (SBG).Five different strains of C.militaris were cultivated on substrates containing rye grains and 0 to 60% SBG.Stromata formation on SBG-containing citronella horse shampoo substrates was noticed with two C.

militaris strains.All strains failed to grow on substrates containing SBG amounts higher than 50%.Highest (10.42 mg/g) cordycepin concentration in cultivating substrate was determined with strain CM2 on 50% SBG.One gram of CM11 strain fungal biomass was able to produce 787.

11 mg/g of cordycepin.SBG as a byproduct represent a readily available, low price substrate for dea eyewear cordycepin solid-state production.Obtained concentrations of cordycepin are so far the highest reported concentrations obtained on solid-state substrates therefore we can talk about cordycepin hyperproduction.